The index had dropped 0.76 percent to end at 1,492.31 points on Tuesday.
The market's breadth was negative with 203 gainers and 267 losers.
During the session, over 1.13 billion shares were traded on the southern bourse, worth nearly VND35.7 trillion (US$1.57 billion).
The VN30-Index, which tracks the 30 biggest stocks on HoSE, rose 2.02 percent, to 1,530.04 points.
Of the VN30 basket, 20 stocks rose, while eight inched lower and two ended flat.
According to financial news site vietstock.vn, banking stocks witnessed a booming session with many strong gainers, in which Bank for Investment and Development of Vietnam (BID), Tien Phong Bank (TPB) and Sacombank (STB) all hit the daily limit gain of 7 percent.
HDBank (HDB) increased by 5.6 percent, Vibank (VIB) rose by 4.9 percent, Saigon-Hanoi Bank (SHB) climbed 4.3 percent, Vietcombank rose 0.8 percent, Techcombank (TCB) increased 4 percent, Military Bank (MBB) gained 4.7 percent, VPBank (VPB) climbed 3.2 percent and Vietinbank (CTG) gained 3.5 percent.
On the other side, real estate stocks were hit strongly by massive selling, with a series of stocks pulled down to the floor prices, such as C.E.O Group JSC (CEO), An Duong Thao Dien JSC (HAR), Hoang Quan Consulting-Trading-Service Real Estate Corporation (HQC), LDG Investment JSC (LDG) and NBB Investment Corporation (NBB).
Eleven out of 25 sector indices on the market recorded gains, including insurance, securities, information and technology, retail, oil and gas, banking and construction materials.
Losers, meanwhile, included wholesale, real estate, healthcare, agriculture, rubber production, food and beverage, seafood production, logistics and construction.
On the Hanoi Stock Exchange (HNX), meanwhile, the HNX-Index lost 1.65 percent to end at 473.64 points on Wednesday.
The northern market index had lost 0.27 percent to end Tuesday at 481.61 points.
During the trading session, investors poured nearly VND4.4 trillion into the bourse, equivalent to a trading volume of more than 135.1 million shares.